Regarding the measurement of adiponectin, we can also mention that adiponectin exists as high-, medium-, and low-molecular-weight isoforms, which may have distinct functions; high-molecular-weight adiponectin may be a better predictor of insulin resistance and diabetes than total adiponectin [38], but in the present study we measured only total adiponectin levels; at 18 years, due to economic reasons, we were able to measure adiponectin in a very small sample. Here, ADIPOQ is linked to Insulin resistance.