FUNDC1 and ischemia: In cardiac ischemia-reperfusion injury (IRI), FUNDC1 mediated mitophagy was induced to degrade mitochondria selectively, and to inhibit apoptosis during the ischemia phase; however, after reperfusion, Ripk3 expression was increased to elevated the mitochondrial apoptosis by inhibiting FUNDC1-modified mitophagy, resulting in the amplified injury of cardiac myocytes and microvascular reperfusion [134].