Several SNPs in the X-linked IRAK1/MECP2 locus have been associated with SLE,by affecting the epigenetic mechanisms of DNA methylation, miRNA expressionand histone modification.15,16 SNPs in this locusupregulate MECP2 isoform 2 mRNA expression in stimulated T cells.15 Also, studies using MECP2 transgenic mouse confirmed the impact ofupregulated MECP2 on all three mechanisms of epigenetic regulationhighlighting the complex pathogenic function of SLE-associated SNPs in this locus.15 Here, IRAK1 is linked to systemic lupus erythematosus.