LGR5 expression in the non-tumoral adjacent tissue of GC patients was mainly localized to the gastric epithelial cells in the basal portion of the glands (Fig. 1 A: 1), with higher intensity in the cell membranes (Fig. 1A: 2) as opposed to their cytoplasms (Fig. 1A: 3). Here, LGR5 is linked to gastric cancer.