Hence, by contributing these new ARUK-UCL annotations, we have greatly expanded the representation of dementia-relevant knowledge in GO, incorporating new GO annotations for four (gene products of CLU, PICALM, APOE, and BIN1) of the 21 gene products previously annotated as a part of the AD-focussed initiative at the University of Toronto [39]. Here, PICALM is linked to Alzheimer disease.