Phosphorylation of PI3K, AKT, and/or mTOR was decreased in hepatocellular carcinoma [46], colorectal cancer [72], and/or breast cancer [37] cell lines in response to siRNA/shRNA-mediated TYRO3 inhibition and phosphorylation of AKT following GAS6 stimulation was abrogated in melanoma cell lines treated with anti-TYRO3 antibodies. This evidence concerns the gene GAS6 and melanoma.