Interestingly, TYRO3 expression was increased in a bone metastatic lesion compared to dormant bone marrow tumor cells isolated from a non-metastatic limb from the same mouse when Du145 prostate cancer cells were implanted subcutaneously on a collagen scaffold and the primary tumor was resected to allow de novo development of metastatic lesions [60]. The gene discussed is TYRO3; the disease is prostate cancer.