Interestingly, TYRO3 expression was increased in a bone metastatic lesion compared to dormant bone marrow tumor cells isolated from a non-metastatic limb from the same mouse when Du145 prostate cancer cells were implanted subcutaneously on a collagen scaffold and the primary tumor was resected to allow de novo development of metastatic lesions [60]. This evidence concerns the gene TYRO3 and Familial prostate cancer.