TYRO3 and neoplasm: Moreover, tumor volume and weight were significantly reduced in immune-compromised mice with a subcutaneous xenograft of HCT116 cells expressing shTYRO3 compared to mice injected with HCT116 cells expressing a control shRNA and in mice with subcutaneous HCT-116 xenografts treated with an anti-TYRO3 antibody compared to mice treated with a control IgG antibody [35].