TYRO3 and Thromboembolism: In Tyro3−/− mice, thrombus size was reduced by 90% compared to wild-type mice after ligation and injection of tissue thromboplastin in the inferior vena cava [26,27] and only 25% of Tyro3−/− mice had a fatal thromboembolism in response to treatment with collagen and epinephrine compared to 80% of wild-type [26].