Ectopic expression of TYRO3 in the MCF10A breast cancer cell line induced AKT phosphorylation in the presence of GAS6 [38] and treatment with GAS6 promoted AKT phosphorylation in the MDA-MB435 melanoma cell line, which expresses TYRO3 but not MERTK or AXL [49]. The gene discussed is AKT1; the disease is breast cancer.