TYRO3 and neoplasm: TYRO3 was also upregulated in paclitaxel-resistant and cisplatin-resistant derivatives of the SKOV3 and A2780 ovarian cancer cell lines, respectively, relative to parental cell lines and siRNA-mediated inhibition of TYRO3 reduced tumor cell expansion in cultures of the paclitaxel-resistant SKOV3 cell line [56,57].