NOTCH1 and systemic sclerosis: These tools revealed that IPF and SSc fibroblast signatures are associated with the activation of several profibrotic signaling pathways such as WNT (Figure 2B), TGF-β (Figure 2C, Figure S3), NOTCH1 (Figure 2D), and HIF1A (Figure 2D), as well as inhibition of the anti-fibrotic PPARG pathway (Figure 2D).