MEST and idiopathic pulmonary fibrosis: Additional miRNA clusters, whereby miRNAs/genes exhibited similar differential gene expression and genomic localization, were identified for miR-17-5p and miR-20a-5p, miR-125b-2-3p and miR-99a-5p, and for miR-335-5p and MEST. This implies that miRNA modules are dysregulated in IPF and SSc fibroblasts and indeed we see significant expression level correlations for the genes within these clusters (data not shown).