TGFB1 and pulmonary fibrosis: Importantly, key fibrosis-associated pathways (e.g., ECM, WNT, and TGF-β) identified from transcriptomic analyses of fibrotic lung tissue were also captured in the gene signatures of isolated fibroblasts, suggesting that the molecular programming in pulmonary fibrosis is driven in large part by fibroblasts/myofibroblasts.