miR-138-5p also reversed expression of a large subset of the disease fibroblast signature, including key pro-fibrotic players such as LOX, CTGF, and GREM1. miR-146b-5p had a more subtle effect on downstream gene expression, however it was the only mimic that significantly reduced ACTA2 levels in SSc fibroblasts. This evidence concerns the gene ACTA2 and systemic sclerosis.