Although the exact mechanisms for the decrease in neuron density, and the differences in glia development observed here in BA 25 in WS are unknown, they may be due in part to the deletion of GTF2I, GTF2IRD1, and FZD9 genes crucially involved in neural development, cell division, and cell fate and neuroinflammatory processes increasing glia and decreasing neuronal survival [37,38,39]. This evidence concerns the gene GTF2IRD1 and Werner syndrome.