PIK3CA is a prominent oncogene, reported as the most commonly aberrant gene within solid tumours; the p110α catalytic subunit is frequently identified and implicated in oncogenesis of many solid tumours, as well as in HNSCCs tumours [41]; with common ‘hotspot’ mutations within its helical domain (p.E545K) and kinase domain (p.H1047L/R) shown to cause oncogenic transformation in mouse models [42]. This evidence concerns the gene PIK3CA and neoplasm.