We have recently shown that in glioblastoma cell lines Caspase-8 expression sustains NF-κB nuclear accumulation and correlates with NF-κB transcriptional activation of several cytokines such ad IL-6, IL-8, VEGF (Vascular Endothelial Growth Factor), IL-1 and βα [18]. The gene discussed is CASP8; the disease is glioblastoma.