We have recently reported that Caspase-8 expression is retained in U87MG and U251MG glioblastoma cell lines and that in these model systems it may promote neoplastic transformation, resistance to anoikis and to therapeutic treatment with temozolomide in vitro [17,18]; furthermore, it sustains NF-κB activation, cytokine production, neoangiogenesis and tumor growth in vitro and in vivo [18]. The gene discussed is NFKB1; the disease is glioblastoma.