CASP8 and cancer: Importantly, Src kinase activity is aberrantly upregulated in many tumors [57]; consistently, the phosphorylation of Caspase-8 on Tyr380 has been reported in several cancer cell lines (including colorectal carcinoma, hepatocellular carcinoma and glioblastoma cell lines) and its occurrence has been correlated with impairment of apoptotic signaling downstream death receptor stimulation and resistance to anoikis [10,17].