Therefore, while downregulation of Caspase-8 in glioblastoma may trigger resistance to apoptosis, it also correlates with a reduction of the level of expression of inflammatory cytokines; indeed the downregulation of Caspase-8 expression in this context results in an increased sensitivity to temozolomide through a still unknown molecular pathway [18]. The gene discussed is CASP8; the disease is glioblastoma.