CD4 and infection: In splenocytes from BALB/c mice infected with B. pseudomallei MSHR5855 there was an early (3–7 days post-infection) increase in both CD4+ and CD8+ T cells (P < 0.001-P < 0.0001) as well as in monocyte/macrophages, NK cells, and granulocytes (Fig 11).