Curiously, previous studies have shown that macrolides Abx have an inhibitory effect on mucus production in airways [27] and is used therapeutically in the treatment for chronic obstructive pulmonary disease (COPD), reducing airway goblet cells production of MUC5AC mucin and alleviating COPD symptoms [28]. The gene discussed is MUC5AC; the disease is chronic obstructive pulmonary disease.