We corroborated that MMP-9 cleaves and inactivates key T-cell chemoattractant CXCR3 ligands (CXCL9, CXCL10, and CXCL11) in vitro, and that anti-MMP-9 treatment may contribute to tumor T-cell homing/trafficking via stabilization of CXCL10 in vivo. This evidence concerns the gene CXCR3 and neoplasm.