For example, variation in HRAS is associated with Costello Syndrome (MIM:218040), variation in KRAS is associated with Noonan Syndrome 3 (MIM:609942) and Cardiofaciocutaneous syndrome 2 (MIM:615278), and variation in NRAS has been observed in probands with Noonan syndrome 6 (MIM:613224) and other RASopathy-associated phenotypes [7]. Here, HRAS is linked to Costello syndrome.