ITGAX and schistosomiasis: This aligns with our recent study, which showed that temporal interference with IL‐4Rα expression by oral administration of tamoxifen in iCre‐/+IL‐4Rα−/lox mice during experimental schistosomiasis reduces perioval granulomatous inflammation, tissue fibrosis, scarring, and hepatosplenomegaly.34 Our observation of a reduced granulomatous inflammation in CD11ccreIL‐4Rα−/lox mice therefore suggests that IL‐4Rα‐expressing CD11c+ cells may be contributing to the fibrogranulomatous tissue inflammation in S. mansoni‐infected mice.