Compared to the normal group, the ALT, CRE, and LDH of all H22 bearing mice groups significantly increased (p < .01), the ALT, CRE, and LDH values in H22 tumor-bearing mice were significantly increased; the values were highest in the model group, which indicated that the functions of heart, liver, and kidney in H22 tumor-bearing mice were damaged. The gene discussed is GPT; the disease is neoplasm.