Curcumin and GAMCLCL exerted their anti-tumor activities by inhibiting of HepG2 cell proliferation, inducing of HepG2 cell apoptosis, reducing of microvascular formation, and inhibiting of tumor angiogenesis and metastasis by decreasing MVD values, down-regulating VEGF, up-regulating caspases 3. Here, CASP3 is linked to neoplasm.