AKT1 and neoplasm: It is believed to affect tumor growth by several different mechanisms which include the induction of HER2 degradation (Klapper et al., 2000), induction of cellular cytotoxicity through recruitment of natural killer cells and cytotoxic proteins (Arnould et al., 2006; Clynes et al., 2000), and inhibition of the PI3K/AKT pathway (Nagata et al., 2004; Zhang et al., 2011).