The upregulation of miR‐150, observed in primary and metastatic melanoma in comparison with congenital nevi (Segura et al., 2010), was implicated in cellular proliferation and cellular migration (Howard et al., 2013; Walker et al., 1998) through the activity of miR‐150 on targets such as v‐myb avian myeloblastosis viral oncogene homolog (MYB), early growth response 2 (EGR2) and neurogenic locus notch homolog protein 3 (NOTCH3), as well as on immune system‐related genes, cytokine signaling cascades and G‐proteins (Fleming et al., 2015; Howard et al., 2013; Kunz, 2013). This evidence concerns the gene NOTCH3 and metastatic melanoma.