MicroRNA miR‐137 acts as tumor suppressor; in fact, the expression of miR‐137 in melanoma leads to the inhibition of the proliferation and invasion by the downregulation of its targets, including MITF, c‐Met, Y‐box‐binding protein 1 (YB‐1) and enhancer of zeste homolog 2 (EZH2). This evidence concerns the gene EZH2 and melanoma.