A second mutation causing the loss of a tumor‐suppressor gene or causing a second mutation could cause a transition from ‘benign’ BRAF‐mutated nevi to malignant melanoma (Arkenau et al., 2011; Jovanovic et al., 2010; McKenzie et al., 2010; Michaloglou et al., 2005). The gene discussed is BRAF; the disease is melanoma.