SYK gene, located on chromosome 9p22 and encoding a non‐receptor type of protein‐tyrosine kinase, that is, widely expressed in hematopoietic cells, is one of the two members of the Syk family (Syk and ZAP‐70), and has been extensively studied as a critical regulator in the pathogenesis of cancer.12 SYK gene polymorphisms have been also reported to be associated with the risk of non‐Hodgkin lymphoma13 and prostate cancer.14 Recently, the role of SYK in vascular inflammation and atherosclerosis has attracted great interest. The gene discussed is SYK; the disease is atherosclerosis.