lnc‐CHOP binds with both CHOP and the C/EBPβ isoform liver‐enriched inhibitory protein, thereby promoting the activation of C/EBPβ and upregulating the expression of ARG1, nitric oxide (NO) synthase 2, NADPH oxidase 2 and cyclooxygenase‐2 (COX2), which are related to the immunosuppressive function of MDSCs in inflammatory and tumour environments (Gao et al., 2018). The gene discussed is PTGS2; the disease is neoplasm.