SIRT1 and metabolic disease: Additionally, it was suggested that HCV core protein might induce lncRNA HOX antisense intergenic RNA (HOTAIR), which is followed by a decrease in expression of Silent information regulator 1 (Sirt1), a histone deacetylase (HDAC) that modulates glucose‐ and lipid‐metabolism‐related gene profiles, resulting in metabolic disorders in hepatocytes (Li et al., 2016).