It was reported by some authors that the production of H2O2 in cancer cells incubated with anticancer compounds, e.g. 2-methoxy-6-acetyl-7-methyl juglone, may by followed by increased NO production mainly via the activation of Jun-N-terminal kinase (JNK) and the expression of inducible nitric oxide synthase (iNOS) [48], thereby leading to NO generation in multiple cancer cells or by xanthine oxidoreductase [57, 58]. Here, MAPK8 is linked to cancer.