Chronic Ataxic Neuropathy with Ophthalmoplegia, M-protein, Cold Agglutinins and Disialosyl antibodies (CANOMAD), is an antibody-associated neuropathy, caused by IgM antibodies targeting disialylated and polysialylated gangliosides, including GD1b, GD3, GT1b and GQ1b [48]. Here, CD40LG is linked to neuropathy.