TNF and rheumatoid arthritis: When RA-HFLS and HFLS were treated with TNF-α at concentration of 30ng/ml for 48h, autophagy was increased both in RA-HFLS group and HFLS group (3.2 fold, 3.0 fold), and HFLS group has a large range of increment compared to the RA-HFLS group.