For example, liver sinusoidal endothelial cells scavenge and cross-present food-borne antigens and induce tolerance through T cell adhesion and sequestration in the liver (40, 41), and tumor-associated LECs cross-present exogenous antigens (42, 43) and maintain peripheral tolerance to self-antigens in LNs (44, 45) dependent on constitutive expression of programmed death-ligand 1 (PD-L1) (45). The gene discussed is CD274; the disease is neoplasm.