In contrast, antibodies against PD-L1/PD-1 or CTLA-4, such as Pembrolizumab (Keytruda), Nivolumab (Opdivo), Atezolizumab (Tecentriq), Avelumab (Bavencio), Durvalumab (Imfinzi), Ipilimumab (Yervoy), can significantly enhance antitumor immunity and the survival of cancer patients. The gene discussed is CD274; the disease is cancer.