Biomarkers most often used include C-reactive protein (CRP), a common biomarker of systemic inflammation (43), N-terminal brain natriuretic peptide (NT-proBNP) used to establish prognosis in heart failure (44), suppressor of tumorigenicity 2 (ST2), a member of the IL-1 receptor family, that signposts cardiac remodeling and tissue fibrosis (45), and galectin-3, which is associated with higher risk of mortality (46). The gene discussed is IL1RL1; the disease is heart failure.