Our study also showed that the exogenous IL-33 leads to the expansion of CD11c+IL-2+ cells (Figures 3M,N) and increased number of CD4+Foxp3+ST2+ (Figures 3C,D) immunoregulatory cells that suppress the development of diabetes in mice treated with IL-33 during the induction of the disease. This evidence concerns the gene CD4 and diabetes mellitus.