Interestingly Oboki et al. (33) did not find the differences in susceptibility to MLD-STZ diabetes between IL-33−/− and “wild type mice.” Although the reason for the discrepancy with our results is not clear, it may be assumed that the lack of endogenous IL-33 does not alter other regulatory mechanisms such as ST2 negative T regulatory cells observed in our previous experiments (15). The gene discussed is IL33; the disease is diabetes mellitus.