Abnormal regulations of TLR7 and TLR9 pathways are indeed critically involved in the activation of macrophages and DCs, subsequently break self-tolerance and contribute to the pathogenesis of SLE through antigen presentation and cytokines production, such as interferons, tumor necrosis factors (TNFs) and specific interleukins (18–20). This evidence concerns the gene TLR9 and systemic lupus erythematosus.