In fact, Lyn has been reported to participate in the development of autoimmune diseases: Lyn can suppress TLR-MyD88 pathway to restrain the development of autoimmunity (40); B cells from SLE patients show decreased Lyn expression which can influence the B cell receptor signaling and B cell hyperactivity (41, 42). The gene discussed is MYD88; the disease is systemic lupus erythematosus.