Syntrophin Beta 2 (SNTB2) suggestes a role in ERK and SR-BI level, and sphingomyelin metabolism in obesity and have been proved to affect the activity of ABCA1 by stabilizing ABCA1 protein, which affect the catabolism of LDL-C level (77–79). Here, ABCA1 is linked to obesity due to melanocortin 4 receptor deficiency.