Because of the young age of onset of pancreatic adenocarcinoma in the patient and a maternal history of breast cancer with a confirmed RAD51C variant (c.790G > A), we performed comprehensive testing to evaluate the following genes: APC, ATM, BMPR1A, BRCA1, BRCA2, BRIP1, CDH1, CDK4, CDKN2A (p14ARF), CDKN2A (p16INK4a), CHEK2, EPCAM, FANCC, MEN1, MLH1, MSH2, MSH6, NBN, NF1, PALB2, PALLD, PMS2, PTEN, RAD51C, RAD51D, SMAD4, STK11, TP53, TSC1, TSC2, and VHL. Results were negative for all genes that were evaluated. The gene discussed is CDKN2A; the disease is pancreatic adenocarcinoma.