NFE2L2 and endothelial dysfunction: For instance, ApoE-/- mice fed with high cholesterol diet supplemented with ellagic acid (EA) exerts an atheroprotective effect by improving the antioxidant capacity, attenuated hypochlorous acid (HOCl)-induced endothelial dysfunction and increased the expression of HO-1 and Nrf2 (Ding et al., 2014).