Increased levels of miR-141 expression in hepatocellular carcinoma cells such as HepG2, SMMC-7721, and HuH7 cell lines has shown to downregulate Keap1 expression via the Keap1 3′ untranslated region (3′ UTR), resulting in transcriptional activation of Nrf2-dependent HO-1 gene (Shi et al., 2015). The gene discussed is KEAP1; the disease is hepatocellular carcinoma.