For instance, ApoE-/- mice fed with high cholesterol diet supplemented with ellagic acid (EA) exerts an atheroprotective effect by improving the antioxidant capacity, attenuated hypochlorous acid (HOCl)-induced endothelial dysfunction and increased the expression of HO-1 and Nrf2 (Ding et al., 2014). This evidence concerns the gene HMOX1 and endothelial dysfunction.