Oxidative stress response can aggravate airway inflammation, previous research showed that the SOD and CAT decreased in the patients with COPD (PMID: 25685791/PMID:23683270); also both the SOD and CAT the same in the animal models of COPD (PMID: 28108387\PMID: 28932196). This evidence concerns the gene SOD1 and chronic obstructive pulmonary disease.