Other pathological parameters are also helpful in AD diagnosis such as measure the concentration of tau protein in CSF, blood, and visualize neurofibrillary tangles mainly composed of hyperphosphorylated tau in the brain by using PET tracers (Chhatwal et al., 2016; Okamura et al., 2016; Olsson et al., 2016; Winston et al., 2016; Saint-Aubert et al., 2017). This evidence concerns the gene MAPT and Alzheimer disease.