CDKN2A and central nervous system cancer: Many tumor suppressor genes in glioma have also been identified, including p16INK4a (Lee et al., 2000), p14ARF (Watanabe et al., 2007), MLH1 (Gömöri et al., 2007) and NDRG2 (Kolodziej et al., 2016; see Table 1).