Banasavadi-Siddegowda et al. (2018) revealed that GBM cells treated with PRMT5 inhibitor mirrored the effects of PRMT5 knockdown, wherein it led to apoptosis of differentiated GBM cells and drove undifferentiated primary patient-derived GBM cells into a non-replicative senescent state. The gene discussed is PRMT5; the disease is glioblastoma.