Decreased levels of the dysbindin subunit have been observed in the hippocampus and prefrontal cortex of post-mortem brain samples from schizophrenic individuals (Talbot et al., 2004, 2011; Weickert et al., 2008; Tang et al., 2009) as well as of the pallidin subunit transcript in human neurones carrying a mutation in MECP2, the gene that causes Rett Syndromes (Larimore et al., 2013). Here, DTNBP1 is linked to Rett syndrome.