MECP2 and intervertebral disk degenerative disorder: A plethora of studies has shown expression of BLOC-1 subunits in brain areas linked to cognitive functions (Talbot et al., 2004, 2006; Weickert et al., 2004; Feng et al., 2008; Tang et al., 2009; Larimore et al., 2013, 2014), and most importantly, drawn a complex interactome for this complex, with some binding partners having a strong association with IDD, including Disrupted in Schizophrenia (DISC)-1, MeCP2 and SNARE proteins (reviewed by Ghiani and Dell’Angelica, 2011; Hartwig et al., 2018).