Most of the ongoing researches have been carried out on SNP rs4950928 in the promoter region of CHI3L1 gene as it was found to be associated with the serum/plasma YKL-40 levels [223, 224] and diseases such as asthma, bronchial hyperresponsiveness [207], and the severity of hepatitis C virus-induced liver fibrosis [225]. This evidence concerns the gene CHI3L1 and Hepatic fibrosis.