PODXL and neoplasm: Thus, we have identified a new mechanism that may drive the morbidity of mutp53-expressing tumours and highlight an intercellular communication pathway consisting of a number of measurable well-characterised components (including Rab35, PODXL, RCP, DGKα, collagen organisation) which are amenable to pharmacological intervention and may constitute viable biomarkers to indicate the presence of metastatic tumours.