However, the fibrillar collagen in the lung parenchyma of mutp53 tumour-bearing mice appeared to be more punctate and less well-organised into long fibres, and the mean decay distance of collagen filaments (as determined using GLCM) was significantly reduced by comparison with those animals with p53 null tumours or non-tumour-bearing animals (Fig. 7a). Here, TP53 is linked to neoplasm.