Podocalyxin (PODXL), a sialomucin associated with cancer aggressiveness18, was significantly suppressed in mutp53R273H-exosomes, and the ability of both the 175 and 273 H mutants of p53 to suppress exosomal PODXL was confirmed by western blotting (Fig. 3b). The gene discussed is TP53; the disease is cancer.