Mac-1 promotes FcγRs mediated neutrophil adhesion and cytolysis of IgG-opsonized targets23–26 and sustains neutrophil adhesion and injury in glomerulonephritis (GN) induced by in situ deposition of anti-glomerular basement membrane (GBM) antibody25,27. This evidence concerns the gene ITGB2 and ganglioneuroma.