Next, we assessed the effect of Mac-1 and LFA-1 on FcγRIIA mediated binding to TNF stimulated human dermal microvascular endothelial cells (HDMEC) coated with anti-endoglin5,6, which models anti-endothelial cell antibody (AECA) deposition observed in autoimmune patients. Here, ITGAL is linked to Autoimmunity.