Furthermore, expression levels of OIP5-AS1 and miR-410 were significantly associated with the pathological grading of glioma, because OIP5-AS1 was notably more highly expressed in high-grade glioma tissues than in low-grade tissues (P<0.05, Figure 1D); however, miR-410 levels were lower in high-grade glioma than in low-grade tissues (P<0.05, Figure 1E). Here, OIP5 is linked to central nervous system cancer.