To explore whether PDIA6 is a relevant hypoxia-regulated factor during AMI, we have tested the in vivo relevance of the identified hypoxia-induced PDIA6 upregulation, which is specific to cardiomyocytes in the mouse model of myocardial infarction by permanent LAD ligation, showing a vast increase in PDIA6 protein expression in the infarcted LAD+ area, but not in the LAD− area (area at risk). The gene discussed is PDIA6; the disease is myocardial infarction.