CD4 and myeloid sarcoma: Guan et al. [65] reported that the level of miRNA let-7e was significantly upregulated in the experimental autoimmune encephalomyelitis (EAE) model of MS, showing the expression as being mainly in CD4+ T cells and with function in enhancement of Th1 and Th17 cells to aggravate EAE, probably by targeting IL-10.