Blockade of the T cell immunoreceptor with Ig and ITIM domains (TIGIT) costimulatory receptor, found on both T cells and NK cells, has been found to alleviate NK cell exhaustion and boost the anti-tumor immune response to PD-(L)1 blockade, with NK cell presence in the TME necessary for the effects of TIGIT or PD-(L)1 blockade [147]. The gene discussed is CD274; the disease is neoplasm.