For instance, loss of the phosphatase and tensin homolog (PTEN), a common event in glioblastoma, prostate cancer, breast cancer, and melanoma, as well as indoleamine 2,3-dioxygenase 1 (IDO1) expression in the TME of soft tissue sarcomas, elicit resistance to ICB. The gene discussed is PTEN; the disease is prostate carcinoma.