Amplification of chromosomal region 9p24.1, which includes the genes PD-L1, PD-L2, and JAK2, was recently found to be a biomarker for high anti-PD(L)-1 response rate in Hodgkin lymphoma [88]; expression of PD-L1 is augmented in this case, not only directly via amplification of PD-L1 itself, but also indirectly through a more active JAK-STAT pathway. This evidence concerns the gene CD274 and Hodgkins lymphoma.