In addition, statistical results showed that PIK3R1 expression was closely associated with lymphatic metastasis (p = 0.029), distal metastasis (p = 0.004) and pathologic tumor, node, metastasis stage (TNM stage, p = 0.002), but not age (p = 0.548), gender (p = 0.484) and tumor size (p = 0.503, Table 1). The gene discussed is PIK3R1; the disease is neoplasm.