MAPK8 and cancer: Interestingly, all four target genes were covered, or at least partially covered, by the five signaling pathways identified: BCL2L1 and IGF1R are involved in PI3K-Akt signaling, IGF1R and MAPK8 in FoxO signaling, IGF1R and FAS in proteoglycans in cancer, and MAPK8 and FAS in MAPK signaling.