PROM1 and breast neoplasm: As it is known that hypoxia may induce the appearance of cells expressing CD133 in breast tumors [23, 26], this cancer stem cell marker was evaluated in MCF10DCIS cultured under low oxygen, showing that the small sub-population of CD133 positive cells detectd at normoxia significantly increased after 96 h of growth under low oxygen availability (Fig. 2d).