The effect of CDCA5 knockdown on tumor proliferation has been demonstrated in other cancers; in studies of oral squamous cell carcinoma and lung carcinogenesis, it was found that CDCA5 functions as a critical gene in proliferation and progression and that in certain cases, targeting CDCA5may be a useful therapeutic intervention [7, 8]. Here, CDCA5 is linked to oral cavity squamous cell carcinoma.