Only vimentin and COX-2 had sufficient staining in normal tissue while the expression of TNF-α, TGF-β, IGFBP-2, IGF-1R was analyzed in cores of tumor tissue only, a potential problem as the histopathological profile of the tumor does not necessarily reflect the conditions of the normal breast tissue representing MD in healthy breasts. The gene discussed is TGFB1; the disease is neoplasm.