In another study, allele-specific expression of several genes in islets (ANPEP, CAMK2B, HMG20A, KCNJ11, NOTCH2, SLC30A8 and WFS1) showed that even subtle changes of gene dosage may have significant consequences for development of type 2 diabetes [40]. This evidence concerns the gene NOTCH2 and type 2 diabetes mellitus.