We found that all these top-ranked miRNAs target those switch genes that are involved in “ECM-receptor interaction” and “focal adhesion” pathways - such as COL5A1, COL6A3, FLNB, ITGA5, MET, THBS1, SDC1, VEGFC - suggesting a further layer of regulation given by miRNAs that could inhibit the “ECM-receptor interaction” and “focal adhesion” pathways by directly targeting switch genes involved in them, and thus promoting cancer invasion and migration. The gene discussed is ITGA5; the disease is cancer.