For the specific case of hsa-let-7b and ATXN2L gene, there is no interaction both in normal tissue and bladder urothelial carcinoma (miRNA/gene p-value in bladder normal tissue: 3.0e−3, miRNA/gene p-value in bladder urothelial cancer: 4.45e−3), instead in breast carcinoma miRNA interacts with its target gene causing its degradation (miRNA/gene p-value in breast normal tissue: 4.55e−3, miRNA/gene p-value in breast cancer tissue: 4.24e−2). The gene discussed is ATXN2L; the disease is breast cancer.